Regeneration of the Nervous System
- Peripheral nervous system axons can be repaired and regenerated to restore function (only partially, and connections are not always as efficient) due to Schwann cell mylination.
- Central nervous system cannot be replaced (oligodendrocytes).
- Environmental factors effect whether the axon’s growth cone is able to repair the damage by growing out.
- Lower amphibians can regenerate both PNS and CNS
o Neuroprogenital cells are more redily recruited to help in urodeles
o Developmental signalling molecules are still expressed in adult urodeles
- Higher vertebrates (chicks) can perform regeneration during development, possibly because neurons are not yet mylinated.
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